Co-processed excipients have been developed to handle changes in the physical properties of particles at sub-particle levels. By co-processing two excipients. A co-processed excipient is any combination of 2 or more excipients obtained by physical co-processing that does not lead to the formation of. co-processed excipients ppt. 1. 1; 2. CO-PROCESSED Presented by- Under the guidance ofMr. Bhaskar N. Bangar Dr. N. H. Aloorkar.
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The mucilage was evaluated for flow properties, Swelling index, loss on drying and FTIR study [ 910 ]. Mucilage and dried KBR were mixed in ratio 1: The protocol of stability studies was in compliance with ICH guidelines for stability testing intended for the zone IVa. Dissolution test was carried out at 75 rpm using ml of 6.
Acetone was added to precipitate the mucilage. The results were represented in Table 3. All materials used in the study complied with pharmaceutical and analytical standards. The blends containing the drug and co-processed excipients were formulated into a tablet by direct compression method. Mucilage exhibited disintegration within 8 sec at the concentration of 1 gm: The granules retained on 16 were collected and stored.
These coprocessed excipients were compressed into tablet form at different concentrations 2. Developing new grades of existing excipients or combination of existing excipients is successful alternative and that can be achieved by means of coprocessing [ 5 ]. Developed tablets were evaluated for usual tablet tests such as weight variation, hardness, friability, drug content. The tapped density was calculated by the formula: The development of new grade of excipient is time consuming and lengthy process and requires regulatory approval as well.
Acacia is used as binder and CaCO 3 as filler. Inhibition of the enzyme decreases de novo cholesterol synthesis, increasing low-density lipoprotein LDL receptors on hepatocytes. For the friability, twenty undusted tablets were weighted, put in the friabilator Electrolab, EF-1W for cycles and re-weighted.
Due to its high swelling index the coprocessed mucilage shows faster disintegration than the coprocessed SSG. It was evaluated for different flow properties and disintegration time.
In this study, acacia and calcium carbonate CaCO 3 were used to prepare a co-processing excipient suitable for the preparation of atorvastatin calcium tablets. The results are depicted in Table 6.
The seeds were soaked in distilled water for 12 hrs and boiled for 30 min. The tablet containing coprocessed mucilage as a superdisintegrant shows fast disintegration and drug release than coprocessed SSG. The present study has been carried out to develop the co-processed excipients in the design and development of atorvastatin calcium tablets using direct compression method.
Table 2 Micromeritic properties of co-processing excipients formulated with different ratios of acacia mucilage and calcium carbonate. The mouth dissolving tablets should disintegrate in less than 30 seconds in a small liquid volume and should have sufficient strength in order to be handled during packaging and transportation [ 4 ].
Formulation and Evaluation of Coprocessed Excipient for Mouth Dissolving Formulation
The comparative study between coprocessed SSG and coprocessed mucilage was excippients Figure 2. Numerous and significant changes in tablet manufacturing have occurred including transition from direct compression to wet and dry granulation. Diversity of their applications such as diluents, binders, disintegrants in tablet make them as alternative to synthetic excipients.
The new trend of using plant derived materials has evoked tremendous interest in pharmaceutical industry. One of the mechanisms of super disintegrant is disintegration by swelling and the mucilage showed excellent swelling property that can be exciipients as a super disintegrant in the preparation of mouth dissolving tablet. A beaker was filled with dissolution medium and suspended in water bath.
All the results of the post-compression tests were satisfactory and were within the pharmacopoeial limits.