In the past decade, HIFU ablation has emerged as a modality for palliative treatment of pancreatic tumors. Multiple preclinical and non-randomized clinical trials. HIFU appears to be an effective tool for pain palliation in advanced pancreatic cancer. Studies assessing treatment in patients with pancreatic. Request PDF on ResearchGate | HIFU for Palliative Treatment of Pancreatic Cancer | High intensity focused ultrasound (HIFU) is a novel.

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The contrast enhanced CT revealed newly found liver metastases marked suggestive of disease progression. A threshold for thermal necrosis, the denaturing of tissue protein, is calculated according to the thermal dose TD formulation:. Analgesic effect of high intensity focused ultrasound therapy for unresectable pancreatic cancer.

HIFU for palliative treatment of pancreatic cancer

Visit for more related articles at JOP. Copyright Journal of Gastrointestinal Oncology. It has been reported to have a high pancreaatic to infiltrate tissues and a strong tendency to metastasise [ 1 ]. J Vasc Interv Radiol.

HIFU for Palliative Treatment of Pancreatic Cancer.

About e cancer Contact e cancer club. The first hyper echogenic changes appeared after seconds as ultrasound US signs of coagulative necrosis. Absorption of ultrasound, the mechanical form of energy, in tissue is not as intuitive as absorption of electromagnetic radiation e.

HIFU pancreattic was delivered using the spot accumulation method where individual spots are treated in an overlapping fashion to treat a volume of tissue Figure 4. Treatment was carefully monitored with US guide and finished when the lesion showed a large part of coagulation necrosis in the centre.

HIFU for Palliative Treatment of Pancreatic Cancer.

The center hole in the transducer is for the ultrasound imaging probe. Probably this type of cancer cell death occurs from immunogenic processes, according to the recent discovery underlying the importance of immunomodulated toxicity, especially observed with the introduction in clinical pratice of checkpoint inhibitors combined with radiation therapy or not.


Contrast enhanced CT or MRI was used to determine the objective tumor response and to assess for any evidence of ablation absence of perfusion on imaging. Chin J Gen Surg. Histopathological features of liver damage induced by laser ablation in rabbits.

In such treatments the thermal effect is usually to be avoided, therefore, short bursts of very high amplitude ultrasound of low frequency usually below 2 MHz are used.

In HIFU the radiating surface is usually spherically curved, so that the ultrasound wave is focused at the center of curvature in a similar fashion to the foor a magnifying lens can focus a broad light beam into a small focal spot Figure 2A.

High intensity focused ultrasound: Each item of the two tools has four response alternatives: There were no severe complications or adverse events related to high intensity focused ultrasound therapy seen in any of the patients treated.

The motion occurs in response to the alternating compression and rarefaction of the surrounding liquid as the acoustic wave hufu through it.

This oscillatory motion causes microstreaming around the bubbles and that, in turn, leads to additional tissue heating cxncer viscous friction, which can lead to coagulative necrosis.

Pain control is an important component of palliation and is commonly performed using opioid therapy and celiac plexus neurolysis. Cases like the one presented are an example of the benefits of this promising new multimodality approach of treatment.

HIFU for palliative treatment of pancreatic cancer

Combination of thermal and cavitation effects to generate deep lesions with an endocavitary applicator using a plane transducer: Hofu treatment was performed with vertical scanning mode separated by 5mm-distance between each slice.

As a result, tissue is heated much faster than it would if nonlinear effects hifuu not occur. At the sixth month of follow-up after the HIFU ablation his GHS improved to 42 and the pancreatic pain was significantly reduced to There were no patients who had a complete response, Multiple nonrandomized studies that followed, mostly from China, provided additional evidence to show that HIFU does provide palliation of tumor-related pain and does not cause adverse effects 12 – 1450 – This case suggests that a multidisciplinary discussion can be useful and beneficial for patients even in a context of metastatic poor prognosis malignancy, like APC.


Preliminary studies have shown that HIFU may also be a useful modality for palliation of cancer-related pain in treamtent with advanced pancreatic cancer 11 – Another important characteristic of an ultrasound wave is its caancer, or the amount of ultrasound energy per unit surface, which is proportional to the square of the wave amplitude. Because of the particular pattern of progression, which was mainly locoregional, with expansive rather than infiltrating picture and it being locally symptomatic, a locoregional treatment was thought would add something in terms of both local tumour growth camcer and quality of life QoL improvement.

In apoptotic cells, the nucleus of the cell self-destructs, with rapid degradation of DNA by endonucleases. A majority of patients diagnosed with pancreatic cancer have advanced disease at the time of diagnosis and are not amenable for surgery with intent to cure. Select your language of interest to view the total content in your interested language.

Journal of the Pancreas. The authors reported no panceratic burns, tumor hemorrhage, large blood vessel rupture, bowel perforation, or pancreatitis following HIFU therapy.