Sign of Leser-Trélat. Authoritative facts about the skin from DermNet New Zealand. Leser-Trélat sign is a rare skin condition characterized by the sudden appearance of seborrheic keratoses that rapidly increase in number and size within weeks. Images in Clinical Medicine from The New England Journal of Medicine — The Sign of Leser–Trélat.

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Leser–Trélat sign – Wikipedia

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Images in clinical medicine. Possible role of retinoid therapy. Andrews’ diseases of the skin: Eruptive seborrheic keratoses have been reported in numerous other clinical scenarios including in patients with erythroderma, pregnant patients, HIV-infected patients, and transplant patients.

Retrieved 15 July Sign in to access your subscriptions Sign in to your personal account. Seborrheic keratoses SK are a nearly ubiquitous benign skin lesion in patients greater than 40 years of age, and generally, even healthy patients may have multiple seborrheic trela.


In addition to the development of new lesions, preexisting ones frequently increase in size and become symptomatic. The Oxford illustrated companion to medicine. Sign in to download free article PDFs Sign in to access your subscriptions Sign in to your personal account.

Sign of Leser-Trélat | DermNet NZ

Obtaining a thorough history, review or systems, and physical examination may help direct the workup of the patient towards a certain malignancy. Register for email alerts with links to free full-text articles Access PDFs of free articles Manage siyn interests Save searches and receive search alerts.

Self-skin examination New smartphone apps to check leserr skin Learn more Sponsored content. In addition, symptomatic lesions may be destroyed with various physical methods including cryotherapy, curettage, shave removal, and electrodesiccation. Epub Mar There is no reported increased predilection amongst either sex or any race.

Patients will often complain of pruritus associated with these lesions.

Purchase access Subscribe to JN Learning for one year. Privacy Policy Terms of Use. Clear Turn Off Zign On. Kurzrock R, Cohen PR. Leser Trelat Sign – StatPearls. Two months before, she had noticed the sudden appearance of many “warts” on her face and neck.


Indian J Dermatol Venereol Leprol.

Malignant Neoplasms and the Leser-Trélat Sign

Epub May Leser-Trelat sign with primary hepatic carcinoma. Additional named growth factors include human-growth-hormone, transforming growth factor-alpha, and insulin-like growth factor. Although these lesions are typically rather easy to distinguish from other melanocytic neoplasms, the histopathological examination may be required for lesions lacking typical skgn findings. A case report and review of the literature.

It is caused by an associated cancer and often occurs with malignant acanthosis nigricans. J Am Acad Dermatol ; Granulocytosis Multicentric reticulohistiocytosis Nonbacterial thrombotic endocarditis. CA Cancer J Clin. If necessary, lesions can be removed using various surgical procedures.

The sign of Leser-Trelat is considered to be a fairly rare paraneoplastic cutaneous marker of internal malignancy with the hallmark finding being an abrupt eruption of multiple seborrheic keratoses. Cutaneous paraneoplastic syndromes in solid tumors.